研究内容

  • 山下グループ

発表論文

2015

Sekimoto, T., Oda, T., Kurashima, K., Hanaoka F., Yamashita T. (2015) Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication. Mol. Cell. Biol.35:699-715.

2014

Kubohara Y., Kikuchi H., Matsuo Y., Oshima Y., Homma Y. (2014) Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum. Biology Open, In press.

2013

Nakajima-Shimada, J., Hatabu, T., Hosoi, Y., Onizuka, Y., Kikuchi, H., Oshima, Y., Kubohara, Y. (2013) Derivatives of Dictyostelium discoideum differentiation-inducing factor-3 suppress the activities of Trypanosoma cruzi in vitro and in vivo. Biochem. Pharmacol. 85 :1603-1610.


Kikuchi, H., Kubohara, Y., Hai, V.N., Katou, Y., Oshima, Y. (2013) Novel chlorinated dibenzofurans Isolated from the cellular slime mold, Polysphondylium filamentosum, and their biological activities. Bioorg. Med. Chem. 21 :4628-4633.


Yamada, Y., Kubohara, Y., Kikuchi, H., Oshima, Y., Wang, H.Y., Ross, S., Williams, J.G. (2013) The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor. Int. J. Dev. Biol. 57 :375-381.

 

Kubohara, Y., Kikuch,i H., Matsuo, Y., Oshima, Y., Homma, Y. (2013) Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum. PLoS ONE 8 (8), e72118.

 

2012

Yamashita, T., Oda, T., Sekimoto, T. (2012) Translesion DNA synthesis and Hsp90. Genes and Environment. 34, 89-93.

 

Yabe, M., Shimizu, T., Morimoto, T., Koike, T., Takakura, H., Tsukamoto, H., Muroi, K., Oshima, K., Asami, K., Takata, M., Yamashita, T., Kato, S., Yabe, H. (2012) Matched sibling donor stem cell transplantation for Fanconi anemia patients with T-cell somatic mosaicism. Pediatr Transplant. 16 :340-345.

 

Seya, K., Kanemaru, K., Matsuki, M., Hongo, K., Kitahara, H., Kikuchi, H., Oshima, Y., Kubohara, Y., Okumura, K., Motomura, S., Furukawa, K. (2012) Br-DIF-1 accelerates dimethyl sulphoxide-induced differentiation of P19CL6 embryonic carcinoma cells into cardiomyocytes. Brit. J. Pharmacol. 165 :870-879.


Tanaka, S., Masuda, Y., Honma, C., Hosaka, K., Takahashi, K., Kubohara, Y. (2012) Manganese promotes phorbol ester–induced interleukin-2 production via AP-1 activation in Jurkat T-cells. Toxicol. Lett. 21 :312-318.

 

Kikuchi, H., Matsuo, Y., Katou, Y., Kubohara, Y., Oshima, Y. (2012) Isolation, synthesis and biological activity of biphenyl and m-terphenyl-type compounds from Dictyostelium cellular slime molds. Tetrahedron 68 :8884-8889.

2011

Pozo F.M., Oda T., Sekimoto T., Murakumo Y., Masutani C., Hanaoka F., Yamashita T. (2011) Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis. Mol. Cell. Biol.31 :3396-3409.

 

Sasaki M., Kawahara K., Nishio M., Mimori K., Kogo R., Hamada K., Itoh B., Wang J., Komatsu Y., Yang Y.R., Hikasa H., Horie Y., Yamashita T., Kamijo T., Zhang Y., Zhu Y., Prives C., Nakano T., Mak T.W., Sasaki T., Maehama T., Mori M., Suzuki A. (2011) Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat. Med. 17 :944-951.

 

Matsushita, N., Endo, Y., Sato, K., Kurumizaka, H., Yamashita, T., Takata, M., Yanagi, S. (2011) Direct Inhibition of TNF-α Promoter Activity by Fanconi Anemia Protein FANCD2. PLoS ONE 6 :e23324.

 

Takahashi, K., Murakami, M., Kikuchi, H., Oshima, Y., Kubohara, Y. (2011) Derivatives of Dictyostelium differentiation-inducing factors promote mitogen-activated IL-2 production via AP-1 in Jurkat cells.
Life Sciences 88 :480-485.


Kuwayama, H., Kikuchi, H. Oshima, Y., Kubohara, Y. (2011) Artificial compounds differentially control Dictyostelium chemotaxis and cell differentiation. Cell Structure and Function 36 :21-26.


Luciani, M-F., Giusti, C., Harms, B., Oshima, Y., Kikuchi, H., Kubohara, Y., Golstein, P. (2011) Atg1 allows second-signalled autophagic cell death in Dictyostelium. Autophagy 7 :501-508.

 

2010

Sekimoto, T., Oda, T., Pozo, F.M., Murakumo, Y., Masutani, C., Hanaoka, F., Yamashita, T. (2010) The molecular chaperone Hsp90 regulates accumulation of DNA polymerase η at replication stalling sites in UV-irradiated cells. Mol. Cell 37 :79-89.

 

Kubohara, Y., Kikuchi, H., Nakamura, K., Matsuo, Y., Oshima, Y. (2010) Preparation of an antibody that recognizes and neutralizes Dictyostelium differentiation-inducing factor-1. Biochem. Biophys. Res. Commun. 396 :364-369.

 

Matsuda, T., Takahashi-Yanaga, F., Yoshihara, T., Maenaka, K., Watanabe, Y., Miwa, Y., Morimoto, S., Kubohara, Y., Hirata, M., Sasaguri, T. (2010) Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity. J. Pharmacol. Sci. 112 :320-326.

 

Kikuchi, H., Ishiko, S., Nakamura, K., Kubohara, Y., Oshima Y. (2010) Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds. Tetrahedron 66 :6000-6007.

 

Calvo-Garrido, J., Carilla-Latorre, S., Kubohara, Y., Santos, N., Mesquita, A., Soldati, T., Golstein, P., Escalante, R.. (2010) Autophagy in Dictyostelium : genes and pathways, cell death and infection. Autophagy 6 :686-701.

 

2009

Paiboonsukwong, K., Ohbayashi, F., Shiiba, H., Aizawa, E., Yamashita, T., Mitani, K. (2009) Correction of mutant Fanconi anemia gene by homologous recombination in human hematopoietic cells using adeno-associated virus vector. J. Gene Med. 11 :1012–1019.

 

Kuwayama, H., Kubohara, Y. (2009) Differentiation-inducing factor-1 and -2 function also as modulators for Dictyostelium chemotaxis. PLoS ONE 4 :e6658.

 

Takahashi, K., Murakami, M., Hosaka, K., Kikuchi, H., Oshima, Y., Kubohara, Y. (2009) Regulation of IL-2 production in Jurkat cells by Dictyostelium-derived factors. Life Sci. 85 :438-43.

 

Luciani, M.-F., Kubohara, Y., Kikuchi, H., Oshima, Y., Golstein, P. (2009) Autophagic or necrotic cell death triggered by distinct motifs of the differentiation factor DIF-1. Cell Death & Differ. 16 :564-570.

 

Kikuchi, H., Hoshi, T., Kitayama, M., Sekiya, M., Katou, Y., Ueda, K., Kubohara, Y., Sato, H., Shimazu, M., Kurata, S., Oshima, Y. (2009) Novel diterpene pyrone-type compounds, Metarhizin A and B, isolated from entomopathogenic fungus, Metarhizium flavoviride and their structural requirements for inhibiting cellular proliferation. Tetrahedron 65 :469-477.

 

Hosomi, O., Misawa, Y., Takeya, A., Matahira, Y., Sugahara, K., Kubohara, Y., Yamaura, F., Kudo, S. (2009) Novel oligosaccharide has suppressive activity against human leukemia cell proliferation. Glycoconjugate J. 26 :189-198.

2008

Hosaka, K., Takahashi, K., Kubohara, Y. (2008) Calcineurin inhibitors present in plastic and rubber products. Jpn. J. Environ. Toxicol. 11 :143-149.

 

Kikuchi, H., Ishiko, S., Oshima, Y., Gonkan, N., Hosaka, K., Kubohara, Y. (2008) Biological activities of novel derivatives of DIF-1 isolated from Dictyostelium. Biochem. Biophys. Res. Commun. 377 :1012-1017.

 

Kubohara, Y., Kikuchi, H., Oshima, Y. (2008) Exploitation of the derivatives of Dictyostelium differentiation-inducing factor-1, which promote glucose consumption in mammalian cells. Life Sci. 83 :608-612.

 

Tungjitwitayakul, J., Singtripop, T., Nettagul, A., Oda, Y., Tatun, N., Sekimoto, T., Sakurai, S. (2008) Identification, characterization, and developmental regulation of two storage proteins in the bamboo borer Omphisa fuscidentalis. J. Insect Physiol. 54 :62-76.

2007

Oda, T., Hayano, T., Miyaso, H., Takahashi, N., Yamashita, T. (2007) Hsp90 regulates the Fanconi anemia DNA damage response pathway. Blood 109 :5016-5026.

 

Yamashita, T., Oda, T., Sekimoto, T. (2007) Hsp90 and the Fanconi anemia pathway: a molecular link between protein quality control and the DNA damage response. Cell cycle 6 :2232-2235.

 

Kubohara, Y., Arai, A., Gokan, N., Hosaka, K. (2007) Pharmacological evidence that stalk cell differentiation involves increases in the intracellular Ca2+and H+ concentrations in Dictyostelium discoideum. Develop. Growth & Differ. 49 :253-264

 

Omata, W., Shibata, H., Nagasawa, M., Kojima, I., Kikuchi, H., Oshima, Y., Hosaka, K., Kubohara, Y. (2007) Dictyostelium differentiation-inducing factor-1 induces glucose transporter 1 translocation and promotes glucose uptake in mammalian cells. FEBS J. 274 :3392-3404.

 

Kikuchi, H., Nakamura, K., Kubohara, Y., Gokan, N., Hosaka, K., Maeda, Y., Oshima, Y. (2007) Dihydrodictyopyrone A and C: New members of dictyopyrone family isolated from Dictyostelium cellular slime molds. Tetrahedron Lett. 48 :5905-5909.

 

Sekimoto, T., Iwami, M., Sakurai, S. (2007) 20-Hydroxyecdysone regulation of two isoforms of the ETS transcription factor E74 gene in programmed cell death in the silkworm anterior silk gland. Insect Mol. Biol. 16 :581-590.

2006

Hamanoue, S., Yagasaki, H., Tsuruta, T., Oda, T., Yabe, H., Yabe, M., Yamashita, T. (2006) Myeloid lineage-selective growth of revertant cells in Fanconi anaemia. Br J Haematol 132 :630-635.

 

Kikuchi, H., Oshama, Y., Ichimura, A., Gokan, N., Hasegawa, A., Hosaka, K., Kubohara, Y. (2006) Anti-leukemic activities of Dictyostelium secondary metabolites: A novel aromatic metabolite, 4-methyl-5-n-pentylbenzene-1,3-diol, isolated from Dictyostelium mucoroides suppresses cell growth in human leukemia K562 and HL-60 cells. Life Sci. 80 :160-165.

 

Sekimoto, T., Iwami, M., Sakurai, S. (2006) Coordinate responses of transcription factors to ecdysone during programmed cell death in the anterior silk gland of the silkworm, Bombyx mori. Insect Mol. Biol. 15 :281-292.

2005

Tanaka, S., Akaishi, E., Hosaka, K., Okamura, S., Kubohara, Y. (2005) Zinc ions suppress mitogen-activated interleukin-2 production in Jurkat cells. Biochem. Biophys. Res. Commun. 335: 162-167.

 

Gokan, N., Kikuchi, H., Nakamura, K., Oshima, Y., Hosaka, K., Kubohara, Y. (2005) Structural requirements of Dictyostelium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyostelium cells and anti-proliferative activity in K562 human leukemic cells. Biochem. Pharmacol. 70: 676-685.

 

Arai, A., Goto, Y., Hasegawa, A., Hosaka, K., Kikuchi, H., Oshima, Y., Tanaka, S., Kubohara, Y. (2005) Dictyopyrones, novel alpha-pyronoids isolated from Dictyostelium spp., promote stalk cell differentiation in Dictyostelium discoideum. Differentiation 73: 377-384.

 

Kikuchi, H., Saito, Y., Sekiya, J., Okano, Y., Saito, M., Nakahata, H., Kubohara, Y. , Oshima, Y. (2005) Isolation and synthesis of a new aromatic compound, brefelamide, from Dictyostelium cellular slime molds and its inhibitory effect on proliferation of astrocytoma cells. J. Org. Chem. 70: 8854-8858.

 

2004

Yagasaki, H., Hamanoue, S., Oda, T. , Nakahata, T., Asano, S., Yamashita, T. (2004) Identification and characterization of novel mutations of the major Fanconi anemia gene FANCA in the Japanese population. Hum Mutat 24 :481-490.

 

Oda, T. , Fukuda, A., Hagiwara, H., Masuho, Y., Muramatsu, M., Hisatake, K., Yamashita, T. (2004) ABT1-associated protein (ABTAP), a novel nuclear protein conserved from yeast to mammals, represses transcriptional activation by ABT1. J Cell Biochem 93 :788-806.

 

Gaston, I., Johnson, K. J., Oda, T. , Bhat, A., Reis, M., Langdon, W., Shen, L., Deininger, M. W., Druker, B. J. (2004) Coexistence of phosphotyrosine-dependent and -independent interactions between Cbl and Bcr-Abl. Exp Hematol 32: 113-121.

 

Akaishi, E., Narita, T., Kawai, S., Miwa, Y., Sasaguri, T., Hosaka, K., Kubohara, Y. (2004) Differentiation-inducing factor-1-induced growth arrest of K562 leukemia cells involves the reduction of ERK1/2 activity. Eur. J. Pharmacol. 485: 21-29.

 

Shimizu, K., Murata, T., Tagawa, T., Takahashi, K., Ishikawa, R., Abe, Y., Hosaka, K.,, Kubohara, Y. (2004) Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an anti-tumor agent isolated from Dictyostelium. Cancer Res. 64: 2568-2571.

 

Kikuchi, H., Sasaki, K., Sekiya, J., Maeda, Y., Amagai, A., Kubohara, Y. , Oshima, Y. (2004) Structural requirements of dictyopyrones isolated from Dictyostelium spp. in the regulation of Dictyostelium development and in anti-leukemic activity. Bioorg. Med. Chem. 12: 3203-3214.

 

Kubohara, Y. , Arai, A., Takahashi, K., Hosaka, K., Okamoto, K. (2004) Prespore-to-stalk conversion involves the production of a pathway-specific glycoprotein, wst25, in the cellular slime mould Dictyostelium discoideum. Biochem. Biophys. Res. Commun. 320: 468-473.

 

2003

Yagasaki, H., Oda, T. , Adachi, D., Nakajima, T., Nakahata, T., Asano, S., Yamashita, T. (2003) Two common founder mutations of the Fanconi anemia group G gene FANCG/XRCC9 in the Japanese population. Hum Mutat 21 :555. (DOI:10,1002/humu.9142)

 

Kanai, M., Konda, Y., Nakajima, T., Izumi, Y., Nanakin, A., Kanda, N., Kubohara, Y. , Chiba, T. (2003) Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK dependent pathway. Oncogene 22: 548-554.

 

Kubohara, Y. , Hanaoka, Y., Akaishi, E., Kobayashi, H., Maeda, M., Hosaka, K. (2003) DIF-1, an anti-tumor agent found Dictyostelium discoideum, inhibits progesterone-induced oocyte maturation in Xenopus laevis. Eur. J. Pharmacol. 460: 93-98.

 

Takahashi-Yanaga, F., Taba, Y., Miwa, Y., Kubohara, Y. , Watanabe, Y., Hirata, M., Morimoto, S., Sasaguri, T. (2003) Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3 beta and degrades cyclin D1 in mammalian cells. J. Biol. Chem. 278: 9663-9670.

 

Takahashi, N., Akaishi, E., Abe, Y., Ishikawa, R., Tanaka, S., Hosaka, K., Kubohara,Y. (2003) Zinc inhibits calcineurin activity in vitro by competing with nickel. Biochem. Biophys. Res. Commun. 307: 64-68.

2002

Adachi, D., Oda, T. , Yagasaki, H., Nakasato, K., Taniguchi, T., D'Andrea, A. D., Asano, S., Yamashita, T. (2002) Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. Hum Mol Genet 11 :3125-3134.

 

Kuno, M., Shimakura. M., Furuta, Y., Terashima, N., Hosaka, K., Kubohara, Y. (2002) Effects of differentiation-inducing factor-1 (DIF-1) of Dictyostelium discoideum on bacteria, fungi, and an influenza virus. Kitakanto Med. J. 52: 253-256.

2001

Yamashita, T., Nakahata, T. (2001) Current knowledge on the pathophysiology of Fanconianemia: from genes to phenotypes. Int J Hematology 74:33-41.

 

Yagasaki, H., Adachi, D., Oda, T., Garcia-Higuera, I., Tetteh, N., D'Andrea, A. D., Futaki, M., Asano, S., Yamashita, T. (2001) A cytoplasmic serine protein kinase binds and may regulate the Fanconi anemia protein FANCA. Blood 98 :3650-3657.

 

Oda, T., Muramatsu, M., Isogai, T., Masuho, Y., Asano, S., Yamashita, T. (2001) HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells. Biochem Biophys Res Commun 288 :1078-1086.

 

Otsuki, T., Furukawa, Y., Ikeda, K., Endo, H., Yamashita, T., Shinohara, A.Iwamatsu, A., Ozawa, K., Liu, J.M. ( 2001 ) Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. Hum Mol Genet 10 :2651-2660.

 

Ooi, J., Isek,i T., Adachi, D., Yamashita, T., Tomonari, A., Tojo, A., Tani, K., Asano, S. (2001) Successful allogeneic bone marrow transplantation for hepatosplenic gamma-T cell lymphoma. Haematologica 86 :E25.

 

Yamashita,T., Nakahata,T.(2001)Current Knowledgeon the pathophysiology of Fanconi anemia:from genes to phenotypes. Int J Hematol 74:33-41.

 

Fujimaki, S., Kubohara, Y. , Kobayashi, I., Kojima, I. (2001) Caspase-independent apoptosis induced by differentiation-inducing factor of D. discoideum in INS-1 cells. Eur. J. Pharmacol . 421: 93-100.

 

Kanno, T., Kubohara, Y. , Goto, F., Takata, K., Hayashi, K. (2001) NMDA-receptor-dependent and -independent cytotoxic effects of D. discoideum differentiation-inducing factor-1 on rat cortical neurons. Develop. Growth & Differ . 43: 709-716.

2000

Futaki, M. Yamashita, T., Yagasaki, H., Toda, T., Yabe, M., Kato, S., Asano, S., Nakahata, T. (2000) The IVS4+4A → T mutation of the Fanconi anemia gene FANCC is not associated with a severe phenotype in Japanese patients. Blood 95 : 1493-1498.

 

Hase, H., Tani, K., Nagayama, H., Watari, K., Takahashi, S., Ooi, J., Shirafuji, N., Iseki, T., Nakazaki, Y., Yamashita, T., Nakamura, T., Masunaga, A., Maekawa, T., Tojo, A., Asano S. (2000)TCR-V beta repertoire analysis with RT-PCR was useful for the early detection of pulmonary relapsed T cell lymphoma after autologous peripheral blood stem cell transplantation. Am J Hematol 64 :124-127.

 

Miwa, Y., Sasaguri, T., Kosaka, C., Taba, Y., Ishida, A., Abumiya, T., Kubohara, Y. (2000) DIF-1, a morphogen of Dictyostelium, induces G1 arrest and differentiation of vascular smooth muscle cells. Circ. Res. 86: 68-75.

 

Kuwayama, H., Oyama, M., Kubohara, Y. , Maeda, M. (2000) A novel role of differentiation-inducing factor-1 in Dictyostelium development, assessed by the restoration of a developmental defect in a mutant lacking mitogen-activated protein kinase ERK2. Develop. Growth & Differ. 42: 531-538.

 

Oda, T., Kayukawa, K., Hagiwara, H., Henrik, T. Y., Masuho, Y., Murakami, Y., Tamura, T., Muramatsu, M. (2000) A novel TATA-binding protein-binding protein, ABT1 activates basal transcription and has a yeast homolog that is essential for growth. Mol Cell Biol 20 :1407-1418.

 

1999

Kupfer, G., Naf, D., Garcia-Higuera, I., Wasiki, J., Cheng, A., Yamashita, T., Tipping, A. Morgan, N., Mathew, C.G., D'Andrea, A.D. (1999) A patient-derived mutant of the Fanconi anemia protein, FANCA, is defective in nuclear accumulation. Exp Hematol 27 : 587-593.

 

Ohata, J., Matsuoka, M., Yamashita, T., Tojo, A., Tani, K., Asano, S. (1999) CD4/CD8 double-positive adult T cell leukemia with preceding cytomegaloviral gastroenterocolitis. Int J Hematol 69 :92-95.

 

Kubohara, Y. (1999) Effects of differentiation-inducing factors (DIFs) of Dictyostelium discoideum on the human leukemia K562 cells: DIF-3 is the most potent anti-leukemic agent. Eur. J. Pharmacol. 381: 57-62.

 

Kubohara, Y. , Hosaka, K. (1999) The putative morphogen, DIF-1, of Dictyostelium discoideum activates Akt/PKB in human leukemia K562 cells. Biochem. Biophys. Res. Commun. 263: 790-796.

Kolibaba, K. S., Bhat, A., Heaney, C., Oda, T., Druker, B. J. (1999) CRKL binding to BCR-ABL and BCR-ABL transformation. Leuk Lymphoma 33 :119-126.

 

1998

Yamashita, T., Kupfer, G.M., Naf, D., Suliman, A., Joenje, H., Asano, S., D'Andrea, A.D.(1998) The Fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation. Proc Natl Acad Sci USA 95 : 13085-13090.

 

Yamashita, T., Wakao, H., Miyajima, A., Asano, S.(1998) Differentiation inducers modulate cytokine signaling pathways in a murine erythroleukemia cell line. Cancer Res 58 : 556-561.

 

Kubohara, Y. , Kabeya, K., Matsui, H., Ishikawa, K. (1998) Effects of DIF-1, an anti-tumor agent isolated from Dictyostelium discoideum , on rat gastric mucosal RGM-1 and leptomeningeal cells. Zool. Sci . 15: 713-721.

Hamada, K., Nakamura, H., Oda, T., Hirano, T., Shimizu, N., Utiyama, H. (1998) Involvement of Mac-1-mediated adherence and sphingosine 1-phosphate in survival of phorbol ester-treated U937 cells. Biochem and Biophys Res Comm 244 :745-750.

 

Nakamura, H., Oda, T., Hamada, K., Hirano, T., Shimizu, N., Utiyama, H. (1998) Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. J Biol Chem 273 :15345-15351.

Bhat, A., Johnson, K. J., Oda, T., Corbin, A. S., Druker, B. J. (1998) Interactions of p62(dok) with p210(bcr-abl) and Bcr-Abl-associated proteins. J Biol Chem 273 :32360-32368.

 

1997

Kupfer, G.M., Yamashita, T., Suliman, A., Asano, S., and D'Andrea A.D. (1997) The Fanconi anemia polypeptide, FAC, binds to the cyclin-dependent kinase, cdc2. Blood 90 :1047-1054.

 

Kubohara, Y. (1997) DIF-1, putative morphogen of D. discoideum , suppresses cell growth and promotes retinoic acid-induced cell differentiation in HL-60. Biochem. Biophys. Res. Commun. 236: 418-422.

 

Asahi, K., Honma, Y., Hazeki, K., Sassa, T., Kubohara, Y. , Sakurai, A., Takahashi, N. (1997) Cotylenin A, a plant-growth regulator, induces the differentiation in murine and human myeloid leukemia cells. Biochem. Biophys. Res. Commun . 238: 758-763.

 

Kubohara, Y. , Maeda, M. (1997) Efficient induction by DIF-1 and 8-bromo cyclic AMP of prespore-to-stalk conversion in Dictyostelium discoideum. Comp. Biochem. Physiol. 118A: 841-845.

 

Heaney, C., Kolibaba, K., Bhat, A., Oda, T., Ohno, S., Fanning, S., Druker, B. J. (1997) Direct binding of CRKL to BCR-ABL is not required for BCR-ABL transformation. Blood 89 :297-306.

 

Bhat, A., Kolibaba, K., Oda, T., Ohno-Jones, S., Heaney, C., Druker, B. J. (1997) Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells. J Biol Chem 272 :16170-16175.

 

Oda, T., Kujovich, J., Reis, M., Newman, B., Druker, B. J. (1997) Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. Oncogene 15 :1255-1262.

 

1996

Yamashita, T., Wu, N., Kupfer, G., Corless, C., Joenje, H., Grompe, M. D'Andrea A.D. (1996) Clinical variability of Fanconi anemia (type C) results from an amino terminal truncated Fanconi anemia complementation group C polypeptide with partial activity. Blood 87 : 4424-4432.

 

Nakamura, Y., Motokura, T., Fujita, A., Yamashita, T., Ogata, E. (1996) Severe hepatitis related to chemotherapy in hepatitis B virus carriers with hematologic malignancies. Survey in Japan, 1987-1991. Cancer 78 : 2210-5.

 

Saito, Y., Kato, M., Kubohara, Y. , Kobayashi, I., Tatemoto, K. (1996) Bradykinin increases intracellular Ca 2+ concentration and promotes insulin secretion in the clonal β -cell line, HIT-T15 cells. Biochem. Biophys. Res. Commun . 221: 577-580.